Open interconnected model of basal ganglia‐thalamocortical circuitry and its relevance to the clinical syndrome of Huntington's disease

@article{Joel2001OpenIM,
  title={Open interconnected model of basal ganglia‐thalamocortical circuitry and its relevance to the clinical syndrome of Huntington's disease},
  author={Daphna Joel},
  journal={Movement Disorders},
  year={2001},
  volume={16}
}
  • D. Joel
  • Published 1 May 2001
  • Psychology, Medicine
  • Movement Disorders
The early stages of Huntington's disease (HD) present with motor, cognitive, and emotional symptoms. Correspondingly, current models implicate dysfunction of the motor, associative, and limbic basal ganglia‐thalamocortical circuits. Available data, however, indicate that in the early stages of the disease, striatal damage is mainly restricted to the associative striatum. Based on an open interconnected model of basal ganglia‐thalamocortical organization, we provide a detailed account of the… Expand
Metabolic and electrophysiological changes in the basal ganglia of transgenic Huntington's disease rats
TLDR
Investigating the metabolic and neuronal activity of basal ganglia nuclei in a transgenic rat model of HD suggests that the globus pallidus and subthalamic nucleus play a role in the neurobiology of HD and can be potential targets for therapeutic interventions. Expand
Can lesions of GPe correct HD deficits?
  • A. Reiner
  • Medicine, Biology
  • Experimental Neurology
  • 2004
TLDR
The basic model better integrates information on basal ganglia anatomy, neurochemistry and physiology, and better predicts specific behavioral abnormalities attending disease-related or drug-related disturbances of specific neuronal populations of the basalganglia than does any prior model. Expand
Loss of Specificity in Basal Ganglia Related Movement Disorders
TLDR
The prevalence of LOS in a many BG-related disorders suggests that neuronal specificity may represent a key feature of normal information processing in the BG system and may underlie a unifying conceptual framework for the BG role in normal and abnormal motor control. Expand
The basal ganglia: a neural network with more than motor function.
  • A. Afifi
  • Biology, Medicine
  • Seminars in pediatric neurology
  • 2003
TLDR
Modifications in the classical models of local connectivity between input and output nuclei of the basal ganglia as well as in the corticobasal ganglia-thalamus-cortical loops have necessitated modifications in the clinical data. Expand
Chapter 12 - Executive Function in Striatal Disorders
Abstract The striatum, part of the basal ganglia complex, has close anatomical and functional ties with the prefrontal and sensorimotor cortices being critical not only for movement planning but alsoExpand
Thalamic atrophy in Huntington's disease co-varies with cognitive performance: a morphometric MRI analysis.
TLDR
It is suggested that thalamic degeneration contributes in an important way to the impairment of executive function in early HD. Expand
Involvement of the subthalamic nucleus in cognitive functions — A concept
TLDR
It is proposed that the non-motor activities in the BG are organized in some way other than the well-known organization of the cortico-BG-thalamocortical circuits, and these findings support the hypothesis of a cortICO-STN bypass of the BG-thal amocortic circuitry under some circumstances. Expand
Morphometric in vivo evidence of thalamic atrophy correlated with cognitive and motor dysfunction in Huntington's disease: The IMAGE-HD study
TLDR
Thalamic atrophy significantly predicted neurocognitive and motor dysfunction within the symp-HD group only, and may be one of the structural bases of the endophenotypic neuroc cognitive and motor manifestations of disease. Expand
Impaired cortico-striatal functional connectivity in prodromal Huntington's Disease
TLDR
Functional integrity of the motor system as a cortico-striatal circuit with particular clinical relevance in HD is assessed to suggest a relation to early structural brain changes in prodromal-HD. Expand
Assessing Topographic Structural Connectivity of the Human Basal Ganglia and Thalamus
TLDR
A novel protocol is introduced that allows for comprehensive in vivo participant-specific probabilistic patterns and visualizations of the structural connections that exist within basal ganglia and thalamic nuclei and is able to map specific parcellations of these nuclei into sub-territories based on their connectivity with primary motor-, and somatosensory cortex. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 241 REFERENCES
Advances in the Understanding of Neural Mechanisms in Movement Disorders
TLDR
Primate models of a spectrum of movement disorders are developed and the neural circuitry which is responsible for mediating them are elucidated and the underlying characteristic changes in neural activity in each of the affected basal ganglia nuclei are defined. Expand
The functions of the basal ganglia and the paradox of stereotaxic surgery in Parkinson's disease.
TLDR
It is concluded that the motor circuits of the basal ganglia are part of a distributed motor system which can operate, albeit imperfectly, in the absence of striato-pallido-thalamo-cortical feedback. Expand
Re-evaluation of the functional anatomy of the basal ganglia in normal and Parkinsonian states
TLDR
This article reviews recent data from different experimental approaches that challenge the established model of basal ganglia organization by reinterpreting the functional interaction between the external segment of the pallidum and the subthalamic nucleus in both the normal and pathological state. Expand
The functional anatomy of basal ganglia disorders
TLDR
A model in which specific types of basal ganglia disorders are associated with changes in the function of subpopulations of striatal projection neurons is proposed, which suggests that the activity of sub Populations of Striatal projections neurons is differentially regulated by striatal afferents and that different striatal projections may mediate different aspects of motor control. Expand
Neurochemical substrates of rigidity and chorea in Huntington's disease.
Huntington's disease is a progressive degenerative neurological disorder which produces a characteristic movement disorder termed chorea. Although chorea is associated with dysfunction of the basalExpand
Dopamine, schizophrenia, mania, and depression: Toward a unified hypothesis of cortico-striatopallido-thalamic function
TLDR
A neural model is described that parallels existing explanations for the etiology of several movement disorders, and may lead to testable inferences regarding the neural substrates of specific psychopathologies. Expand
Early Loss of Neostriatal Striosome Neurons in Huntington's Disease
TLDR
Analysis of the functional circuitry of the basal ganglia suggests that early degeneration of striosomal neurons may produce hyperactivity of the nigrostriatal dopaminergic pathway, causing chorea and other early clinical manifestations of HD. Expand
Clinical‐pathologic correlation in Huntington's disease
TLDR
It is demonstrated that cognitive impairment is a clear-cut characteristic of early HD that is linked closely to the extent of caudate atrophy as measured by CT. Expand
Basal ganglia and movement disorders: an update
TLDR
Patterns of electrophysiological activity and changes in indices of GABA-dependent transmission in the external pallidum lead to a reconsideration of the mechanisms responsible for these changes in output activity. Expand
Cognitive deficits in Huntington's disease are predicted by dopaminergic PET markers and brain volumes.
TLDR
The overall data pattern is consistent with the view that Huntington's disease may be characterized as a frontostriatal dementia, in which cognitive deficits may result from pathological changes at multiple sites in the frontostRIatal circuitry. Expand
...
1
2
3
4
5
...