Open field locomotor effects in rats after intraventricular injections of ethanol and the ethanol metabolites acetaldehyde and acetate

@article{Correa2003OpenFL,
  title={Open field locomotor effects in rats after intraventricular injections of ethanol and the ethanol metabolites acetaldehyde and acetate},
  author={Merc{\'e} Correa and Maria N. Arizzi and Anthony Betz and Susana Mingote and John D Salamone},
  journal={Brain Research Bulletin},
  year={2003},
  volume={62},
  pages={197-202}
}
The typical response to acute peripheral administration of low to high doses of ethanol in rats is a dose-dependent depression of motor activity. Nevertheless, recent studies indicate that intraventricular (ICV) injections of ethanol can produce signs of behavioral activation. In addition, considerable evidence indicates that brain metabolism of ethanol is involved in modulating some of the behavioral effects of this drug, which suggests that ethanol may have active metabolites with central… CONTINUE READING

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