Open conformers: the hidden face of MHC-I molecules.

@article{Arosa2007OpenCT,
  title={Open conformers: the hidden face of MHC-I molecules.},
  author={Fernando A. Arosa and Susana Gomes Santos and Simon J Powis},
  journal={Trends in immunology},
  year={2007},
  volume={28 3},
  pages={
          115-23
        }
}
A pool of MHC-I molecules present at the plasma membrane can dissociate from the peptide and/or the light chain, becoming open MHC-I conformers. Whereas peptide-bound MHC-I molecules have an important role in regulating adaptive and innate immune responses, through trans-interactions with T cell and NK cell receptors, the function of the open MHC-I conformers is less clear but seems to be related to their inherent ability to cis-associate, both with themselves and with other receptors. Here, we… CONTINUE READING

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