Open channel block of Kv3.1 currents by fluoxetine.

  title={Open channel block of Kv3.1 currents by fluoxetine.},
  author={Min Ji Sung and Hye Sook Ahn and Sang June Hahn and Bok Hee Choi},
  journal={Journal of pharmacological sciences},
  volume={106 1},
The action of fluoxetine, a serotonin reuptake inhibitor, on the cloned neuronal rat Kv3.1 channels stably expressed in Chinese hamster ovary cells was investigated using the whole-cell patch-clamp technique. Fluoxetine reduced Kv3.1 whole-cell currents in a reversible, concentration-dependent manner, with an IC(50) value and a Hill coefficient of 13.4 muM and 1.4, respectively. Fluoxetine accelerated the decay rate of inactivation of Kv3.1 currents without modifying the kinetics of current… CONTINUE READING

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