Open-and-shut cases in coiled-coil assembly: alpha-sheets and alpha-cylinders.

  title={Open-and-shut cases in coiled-coil assembly: alpha-sheets and alpha-cylinders.},
  author={John Walshaw and Derek N. Woolfson},
  journal={Protein science : a publication of the Protein Society},
  volume={10 3},
The coiled coil is a ubiquitous protein-folding motif. It generally is accepted that coiled coils are characterized by sequence patterns known as heptad repeats. Such patterns direct the formation and assembly of amphipathic alpha-helices, the hydrophobic faces of which interface in a specific manner first proposed by Crick and termed "knobs-into-holes packing". We developed software, SOCKET, to recognize this packing in protein structures. As expected, in a trawl of the protein data bank, we… CONTINUE READING