Open Source Drug Discovery: Finding a Niche (or Maybe Several)

@article{Maurer2007OpenSD,
  title={Open Source Drug Discovery: Finding a Niche (or Maybe Several)},
  author={Stephen M. Maurer},
  journal={Product Innovation eJournal},
  year={2007}
}
  • S. M. Maurer
  • Published 1 April 2007
  • Law
  • Product Innovation eJournal
Despite their novelty and importance, open source methods have been largely been limited to software. However, scholars have long suggested that it would be logical to organize at least one other field - drug discovery - using open source principles. This paper reviews today's relatively tentative attempts to organize open source biology collaborations and argues that more ambitious projects are feasible. Five specific projects are proposed and analyzed in detail. The article concludes by… 
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lawcat.berkeley.edu:443
28 Citations
Highly Influential Citations
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28 Citations

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References

SHOWING 1-10 OF 66 REFERENCES
Can open-source R&D reinvigorate drug research?
  • B. Munos
  • Biology
    Nature Reviews Drug Discovery
  • 2006
The low number of novel therapeutics approved by the US FDA in recent years continues to cause great concern about productivity and declining innovation. Can open-source drug research and…
Open Source Research — the Power of Us
TLDR
Open source research holds great promise for solving complex problems in areas where profit-driven research is seen to have failed, and is illustrated with a specific problem in organic chemistry that is thought to be solved substantially faster with an open source approach.
The Penguin's Genome, or Coase and Open Source Biotechnology
Open source offers an interesting alternative to government control or private bargaining over rights to a commons. Open source production, however, will not occur on any significant scale absent…
The Open Source Biotechnology Movement: Is it Patent Misuse?
Fledgling efforts exist to establish open-source projects in biotechnology. Following copyleft, participants agree that advances in the technology must remain as openly available as the original…
Commons-Based Strategies and the Problems of Patents
TLDR
This Policy Forum reviews the experience of free software, distributed computing, and other forms of commons-based peer production and proposes two complementary avenues open to scientists and universities to alleviate the costs of overly protective patent systems.
Harnessing and Sharing the Benefits of State-Sponsored Research: Intellectual Property Rights and Data Sharing in California's Stem Cell Initiative
TLDR
How IP law affects data-sharing is considered, and four specific sets of issues that public sponsors of data-rich research, including CIRM, are likely to confront are discussed: how to motivate researchers to contribute data; who may have access to the data and on what conditions; how to establish database architecture and curate and maintain the database.
Gene-function wiki would let biologists pool worldwide resources
TLDR
A ‘gene function’ equivalent of Wikipedia is proposed for science, where the average biologist has little notion as to what most of them do, and has to start ploughing through the literature.
Finding Cures for Tropical Diseases: Is Open Source an Answer?
The Tropical Disease Initiative will be a Web-based, community- wide effort where scientists from the public and private sectors join together to discover new treatments
The Major Role of Clinicians in the Discovery of Off‐Label Drug Therapies
TLDR
The role of clinicians in the discovery of off‐label use of prescription drugs approved by the United States Food and Drug Administration is investigated.
Is the Pharmaceutical Industry in a Productivity Crisis?
  • I. Cockburn
  • Economics, Political Science
    Innovation Policy and the Economy
  • 2006
Rising R&D expenditures and falling counts of new drug approvals since 1996 have lead many observers to conclude that there has been a sharp decline in research productivity in the pharmaceutical…
...
...