• DOI:10.1006/exnr.2000.7503
• Corpus ID: 9997358

Open-Loop and Closed-Loop Optokinetic Nystagmus (OKN) in Myasthenia Gravis and Nonmyasthenic Subjects

@article{Yang2000OpenLoopAC,
  title={Open-Loop and Closed-Loop Optokinetic Nystagmus (OKN) in Myasthenia Gravis and Nonmyasthenic Subjects},
  author={Qing Yang and Min Wei and Fuchuan Sun and Jing Tian and Xiangjun Chen and Chuanzhen Lu},
  journal={Experimental Neurology},
  year={2000},
  volume={166},
  pages={166-172}
}

• Qing Yang, M. Wei, +3 authors Chuanzhen Lu
• Published 1 November 2000
• Medicine
• Experimental Neurology

Optokinetic nystagmus (OKN) eye movements of myasthenia gravis (MG) and nonmyasthenic ocular palsies, and normal subjects were examined under closed-loop and open-loop conditions. The open-loop OKN condition was achieved by adding the signal of eye-movement velocity of OKN to the computer-generated signal controlling the stimulus grating moving. The OKN was recorded by means of electromagnetic search scleral coil technique. In MG patients, the open-loop gains of OKN increased significantly after the intramuscular injection of an acetylcholinesterase inhibitor, neostigmine, while the closed-loop OKN gains were not significantly changed. Both the closed-loop and open-loop OKN gains of normal subjects and nonmyasthenic patients were not increased for the administration of neostigmine. The experimental results indicated that the open-loop OKN gain could be sensitive to reflect the changes of the function of neuromuscular junction in MG patients.