Open‐label study of oral CEP‐701 (lestaurtinib) in patients with polycythaemia vera or essential thrombocythaemia with JAK2‐V617F mutation

@article{Hexner2014OpenlabelSO,
  title={Open‐label study of oral CEP‐701 (lestaurtinib) in patients with polycythaemia vera or essential thrombocythaemia with JAK2‐V617F mutation},
  author={Elizabeth O. Hexner and Gail J. Roboz and Ronald Hoffman and Selina M. Luger and John O. Mascarenhas and Martin P. Carroll and Regina Clementi and Debra M. Bensen-Kennedy and Alison R. Moliterno},
  journal={British Journal of Haematology},
  year={2014},
  volume={164}
}
JAK2‐V617F is central to the pathogenesis of myeloproliferative neoplasms. We examined whether lestaurtinib decreased JAK2‐V617F allele burden and evaluated its clinical benefits and tolerability in patients with polycythaemia vera (PV) and essential thrombocythaemia (ET). This phase 2, open‐label, multicentre study was designed to detect ≥15% reduction in JAK2‐V617F allele burden in 15% of patients. Eligible patients received lestaurtinib 80 mg twice daily for 18 weeks and could participate in… 
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