Opantimycin A, a new metabolite isolated from Streptomyces sp. RK88-1355

@article{Nogawa2017OpantimycinAA,
  title={Opantimycin A, a new metabolite isolated from Streptomyces sp. RK88-1355},
  author={Toshihiko Nogawa and Akiko Okano and Chung Liang Lim and Yushi Futamura and Takeshi Shimizu and Shunji Takahashi and Darah Ibrahim and Hiroyuki Osada},
  journal={The Journal of Antibiotics},
  year={2017},
  volume={70},
  pages={222-225}
}
A new metabolite containing a γ-butyrolactone and 2-hydroxy-3formylaminobenzoic acid moieties, opantimycin A (1) was isolated from a microbial metabolite fraction library generated from Streptomyces sp. RK88-1355 by search of an LC/MS-based spectral database named NPPlot: Natural Products Plot. The structure of 1 was determined based on extensive spectroscopic methods including NMR, MS and MS/MS experiments. 1 showed moderate cytotoxicity against HL-60 cell lines and antimalarial activity… 

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