Op18 reveals the contribution of nonkinetochore microtubules to the dynamic organization of the vertebrate meiotic spindle.

@article{Houghtaling2009Op18RT,
  title={Op18 reveals the contribution of nonkinetochore microtubules to the dynamic organization of the vertebrate meiotic spindle.},
  author={Benjamin R. Houghtaling and Ge Yang and Alexandre Matov and Gaudenz Danuser and Tarun M Kapoor},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 36},
  pages={15338-43}
}
Accuracy in chromosome segregation depends on the assembly of a bipolar spindle. Unlike mitotic spindles, which have roughly equal amounts of kinetochore microtubules (kMTs) and nonkinetochore microtubules (non-kMTs), vertebrate meiotic spindles are predominantly comprised of non-kMTs, a large subset of which forms an antiparallel "barrel" array at the spindle equator. Though kMTs are needed to drive chromosome segregation, the contributions of non-kMTs are more mysterious. Here, we show that… CONTINUE READING
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