Op18/stathmin caps a kinked protofilament-like tubulin tetramer.

  title={Op18/stathmin caps a kinked protofilament-like tubulin tetramer.},
  author={Michel O. Steinmetz and Richard A. Kammerer and Wolfgang Jahnke and Kenneth N. Goldie and Ariel Lustig and Jan van Oostrum},
  journal={The EMBO journal},
  volume={19 4},
Oncoprotein 18/stathmin (Op18), a regulator of microtubule dynamics, was recombinantly expressed and its structure and function analysed. We report that Op18 by itself can fold into a flexible and extended alpha-helix, which is in equilibrium with a less ordered structure. In complex with tubulin, however, all except the last seven C-terminal residues of Op18 are tightly bound to tubulin. Digital image analysis of Op18:tubulin electron micrographs revealed that the complex consists of two… CONTINUE READING

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