Oophorectomy-induced bone loss is attenuated in MAGP1-deficient mice.

  title={Oophorectomy-induced bone loss is attenuated in MAGP1-deficient mice.},
  author={Clarissa S. Craft and Thomas J Broekelmann and Wei Zou and Jean C Chappel and Steven L Teitelbaum and Robert P. Mecham},
  journal={Journal of cellular biochemistry},
  volume={113 1},
Microfibril-associated glycoprotein-1 (MAGP1), together with the fibrillins, are constitutive components of vertebrate microfibrils. Mice deficient in MAGP1 (murine MAGP1 knockout animals (Mfap2(-/-)); MAGP1Δ) is appropriate develop progressive osteopenia and reduced whole bone strength, and have elevated numbers of osteoclasts lining the bone surface. Our previous studies suggested that the increased osteoclast population was associated with elevated levels of receptor activator of NF-κB… CONTINUE READING


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