Oophorectomy after menopause and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers.

@article{Kotsopoulos2012OophorectomyAM,
  title={Oophorectomy after menopause and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers.},
  author={Joanne Kotsopoulos and Jan A. Lubiński and Henry T. Lynch and C Kim-sing and Susan L. Neuhausen and Rochelle Demsky and William D Foulkes and Parviz Ghadirian and Nadine M. Tung and Peter Mark Ainsworth and Leigha A. Senter and Beth Y. Karlan and Andrea Eisen and Charis Eng and Jeffrey N. Weitzel and Dawna M. Gilchrist and Joanne L. Blum and Dana Zakalik and Christian F Singer and Taya Fallen and O Ginsburg and Tomasz Huzarski and Ping Sun and Steven A Narod},
  journal={Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology},
  year={2012},
  volume={21 7},
  pages={1089-96}
}
BACKGROUND To evaluate the effect of the cumulative number of ovulatory cycles and its contributing components on the risk of breast cancer among BRCA mutation carriers. METHODS We conducted a matched case-control study on 2,854 pairs of women with a BRCA1 or BRCA2 mutation. Conditional logistic regression was used to estimate the association between the number of ovulatory cycles and various exposures and the risk of breast cancer. Information from a subset of these women enrolled in a… CONTINUE READING