Oocytes determine cumulus cell lineage in mouse ovarian follicles.

  title={Oocytes determine cumulus cell lineage in mouse ovarian follicles.},
  author={Francisco J Alvarez D{\'i}az and Karen Wigglesworth and John J. Eppig},
  journal={Journal of cell science},
  volume={120 Pt 8},
The two principal functions of ovarian follicles are developmental and endocrine. The cumulus cells surrounding the oocyte are specialized to serve the development of the oocyte and steroidogenesis is a principal role of mural granulosa cells that line the follicle wall. The findings in this report demonstrate that oocytectomy or treatment with an inhibitor of SMAD2/3 activation results in decreased cumulus marker mRNA transcript levels and allows FSH to induce mural marker transcripts in… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.


Publications citing this paper.
Showing 1-10 of 71 extracted citations

GDF-9 and BMP-15 direct the follicle symphony

Journal of Assisted Reproduction and Genetics • 2018
View 1 Excerpt


Publications referenced by this paper.
Showing 1-10 of 46 references

TGF -  superfamily members and ovarian follicle development

C. Glister
Reproduction • 2006
View 1 Excerpt

Similar Papers

Loading similar papers…