Oocytes determine cumulus cell lineage in mouse ovarian follicles.

@article{Daz2007OocytesDC,
  title={Oocytes determine cumulus cell lineage in mouse ovarian follicles.},
  author={Francisco J Alvarez D{\'i}az and Karen Wigglesworth and John J. Eppig},
  journal={Journal of cell science},
  year={2007},
  volume={120 Pt 8},
  pages={1330-40}
}
The two principal functions of ovarian follicles are developmental and endocrine. The cumulus cells surrounding the oocyte are specialized to serve the development of the oocyte and steroidogenesis is a principal role of mural granulosa cells that line the follicle wall. The findings in this report demonstrate that oocytectomy or treatment with an inhibitor of SMAD2/3 activation results in decreased cumulus marker mRNA transcript levels and allows FSH to induce mural marker transcripts in… CONTINUE READING

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TGF -  superfamily members and ovarian follicle development

C. Glister
Reproduction • 2006
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