Oocyte-secreted factors: regulators of cumulus cell function and oocyte quality.

  title={Oocyte-secreted factors: regulators of cumulus cell function and oocyte quality.},
  author={Robert Bruce Gilchrist and Michelle T Lane and Jeremy G. Thompson},
  journal={Human reproduction update},
  volume={14 2},
Oocyte quality is a key limiting factor in female fertility, yet we have a poor understanding of what constitutes oocyte quality or the mechanisms governing it. The ovarian follicular microenvironment and maternal signals, mediated primarily through granulosa cells (GCs) and cumulus cells (CCs), are responsible for nurturing oocyte growth, development and the gradual acquisition of oocyte developmental competence. However, oocyte-GC/CC communication is bidirectional with the oocyte secreting… CONTINUE READING
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