Oocyte regulation of kit ligand expression in mouse ovarian follicles.

  title={Oocyte regulation of kit ligand expression in mouse ovarian follicles.},
  author={Ieuan M Joyce and Frank L Pendola and Karen Wigglesworth and John J. Eppig},
  journal={Developmental biology},
  volume={214 2},
Kit ligand (KL), a product of granulosa cells in ovarian follicles, is a putative regulator of oocyte development. However, the factors that regulate KL mRNA levels in granulosa cells remain unclear. This study tested the hypothesis that oocytes regulate granulosa cell steady-state KL mRNA expression levels and that the characteristics of this regulation are dependent on the stage of growth and development of both oocytes and follicles. Levels of mRNA for the KL splice variants (KL-1 and KL-2… CONTINUE READING
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