Oocyte donation in humans: a model to study the effect of age on embryo implantation rate.

@article{Balmaceda1994OocyteDI,
  title={Oocyte donation in humans: a model to study the effect of age on embryo implantation rate.},
  author={Jos{\'e} Pedro Balmaceda and Luca M Bernardini and I Ciuffardi and Carlos J. Felix and Teri S Ord and Carlos E. Sueldo and R. Asch},
  journal={Human reproduction},
  year={1994},
  volume={9 11},
  pages={2160-3}
}
Although a number of different mechanisms have been suggested to account for the decline of fertility with age, the majority of studies agree that poor oocyte quality and reduced endometrial receptivity are the most important. In fact, the increased incidence of early pregnancy loss and chromosomal abnormalities of oocytes in older women, as well as the ability to reverse decreasing pregnancy rates by using oocyte donation, strongly support the evidence that oocyte ageing is the main factor… CONTINUE READING