Oocyte aging: cellular and molecular changes, developmental potential and reversal possibility.

@article{Miao2009OocyteAC,
  title={Oocyte aging: cellular and molecular changes, developmental potential and reversal possibility.},
  author={Yi-Liang Miao and Kazuhiro Kikuchi and Qing-Yuan Sun and Heide Schatten},
  journal={Human reproduction update},
  year={2009},
  volume={15 5},
  pages={573-85}
}
BACKGROUND In humans, normal healthy children are regularly produced through fertilization of fresh oocytes with fresh spermatozoa. However, asynchrony between oocytes and spermatozoa, especially when aged oocytes are fertilized by fresh or senescent spermatozoa, will not only affect the rate of fertilization and pre- and post-implantation embryo development but also the life of the offspring. As many failures in assisted reproduction technologies (ART) are related to oocyte aging, new methods… CONTINUE READING
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