Oocyte Generation in Adult Mammalian Ovaries by Putative Germ Cells in Bone Marrow and Peripheral Blood

@article{Johnson2005OocyteGI,
  title={Oocyte Generation in Adult Mammalian Ovaries by Putative Germ Cells in Bone Marrow and Peripheral Blood},
  author={J. Johnson and J. Bagley and Malgorzata Skaznik-Wikiel and Ho-Joon Lee and G. Adams and Y. Niikura and Katherine S. Tschudy and J. C. Tilly and M. L. Cort{\'e}s and Randolf Forkert and T. Spitzer and J. Iacomini and D. Scadden and J. Tilly},
  journal={Cell},
  year={2005},
  volume={122},
  pages={303-315}
}
  • J. Johnson, J. Bagley, +11 authors J. Tilly
  • Published 2005
  • Medicine, Biology
  • Cell
  • It has been suggested that germline stem cells maintain oogenesis in postnatal mouse ovaries. Here we show that adult mouse ovaries rapidly generate hundreds of oocytes, despite a small premeiotic germ cell pool. In considering the possibility of an extragonadal source of germ cells, we show expression of germline markers in bone marrow (BM). Further, BM transplantation restores oocyte production in wild-type mice sterilized by chemotherapy, as well as in ataxia telangiectasia-mutated gene… CONTINUE READING

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    INTERVENTIONAL CLINICAL TRIAL
    Women delay maternity and, as a consequence, available oocyte number and their quality decrease (9-18% of all IVF patients). Different treatment protocols have been developped… Expand
    ConditionsOvarian Reserve
    InterventionProcedure
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