Onzin, a c-Myc-repressed target, promotes survival and transformation by modulating the Akt–Mdm2–p53 pathway

@article{Rogulski2005OnzinAC,
  title={Onzin, a c-Myc-repressed target, promotes survival and transformation by modulating the Akt–Mdm2–p53 pathway},
  author={Kenneth Rogulski and Youjun Li and Kristi Rothermund and Lixia Pu and Simon Watkins and Fenghua Yi and Edward V. Prochownik},
  journal={Oncogene},
  year={2005},
  volume={24},
  pages={7524-7541}
}
The c-Myc oncoprotein is a general transcription factor whose target genes dictate the c-Myc phenotype. One such target of c-Myc, ‘onzin’, is normally expressed at high levels in myeloid cells and is dramatically downregulated in response to c-Myc overexpression. We show here that short hairpin interfering RNA-mediated knockdown of endogenous onzin results in a reduced growth rate and a proapoptotic phenotype. In contrast, onzin overexpression in fibroblasts is associated with an increased… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 15 references

( 2001 – 2002 )

M. Oren
Mol . Cell . Biol • 2003

Adv

DA Vargas, S Takahashi, Z. Ronai
Cancer Res., 89, 1–34. • 2003
View 1 Excerpt

Cancer Treat

J Paez, Sellers WR.
Res., 115, 145–167. • 2003

Drug Resist

KA West, SS Castillo, PA. Dennis
Update, 5, 234–248. • 2002
View 1 Excerpt

J

X Yin, L Grove, K Rogulski, EV. Prochownik
Biol. Chem., 277, 19998–20010. • 2002

Semin

BP Zhou, Hung MC.
Oncol., 29, 62–70. • 2002

Trends Biochem

LD Mayo, Donner DB.
Sci., 27, 462–467. • 2002

Proc

JR Testa, A. Bellacosa
Natl. Acad. Sci. USA, 98, 10983–10985. • 2001

Biochem

B Vanhaesebroeck, Alessi DR.
J., 346, 561–576. • 2000

Mol

KS Voo, DL Carlone, BM Jacobsen, A Flodin, DG. Skalnik
Cell. Biol., 20, 2108–2121. • 2000

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