Onychomycosis: a review

  title={Onychomycosis: a review},
  author={A.K. Gupta and Nadia Stec and Richard C Summerbell and Neil H. Shear and Vincent Piguet and Antonella Tosti and Bianca Maria Piraccini},
  journal={Journal of the European Academy of Dermatology and Venereology},
  • A. GuptaN. Stec B. Piraccini
  • Published 1 April 2020
  • Medicine, Biology
  • Journal of the European Academy of Dermatology and Venereology
Onychomycosis is a fungal infection of the nail, causing discoloration and thickening of the affected nail plate, and is the most common nail infection worldwide. Onychomycosis was initially thought to be predominantly caused by dermatophytes; however, new research has revealed that mixed infections and those caused by non‐dermatophyte moulds (NDMs) are more prevalent than previously thought, especially in warmer climates. Microscopy and fungal culture are the gold standard techniques for… 

Updated Perspectives on the Diagnosis and Management of Onychomycosis

Onychomycosis is a chronic disease with high recurrence rates and patients should be counseled on an appropriate plan to minimize recurrence risk following effective antifungal therapy, and Physicians should consider the disease severity, infecting pathogen, medication safety, efficacy and cost, and patient age, comorbidities, medication history, and likelihood of compliance when determining management plans.

Book Chapter Candida Onychomycosis: Mini Review

Clinical manifestation of CO varies, from discoloration and marked thickening of the nail to dystrophic nails with fingernails more commonly affected, and microscopic examination and fungal cultures are the gold standard examination for diagnosing onychomycosis.

Transmission of Onychomycosis and Dermatophytosis between Household Members: A Scoping Review

Recommendations that aim to interrupt household transmission of onychomycosis are provided, based on findings that the underlying mechanisms and risk factors for transmission between household members are incompletely understood.

Strategies to improve the diagnosis and clinical treatment of dermatophyte infections.

Properties of natural herbal, laser, and photodynamic treatments can be used as alternative treatments in patients who cannot tolerate topical and systemic antifungal treatments, especially in immunosuppressed patients.

Onychomycosis in children – review on treatment and management strategies

Per-weight dosing regimens of systemic antifungal agents such as terbinafine, itraconazole, and fluconazole are found to be safe in children and are used off-label for the treatment of pediatric onychomycosis with high efficacy.

Diagnosing Onychomycosis: What’s New?

Clinicians need to be aware of the limitations of diagnostic utility calculations as well, and look beyond the numbers to assess which techniques will provide the best options for patient assessment and management.

Onychomycosis in Older Adults: Prevalence, Diagnosis, and Management

Older patients should practice sanitization techniques, consider lifestyle changes, and perhaps consider using a topical antifungal as long-term maintenance therapy one to three times per week to prevent the recurrence of onychomycosis or to treat early disease.

Quality of life and therapeutic regimen management in onychomycosis patients and in vitro study of antiseptic solutions

In vitro fungicidal properties of the antiseptics povidone-iodine, polyhexamethylene biguanide-betaine, octenidine dihydrochloride, and a super-oxidized solution against two ATCC strains and three clinical fungal isolates from Hospital patients suggest that they may constitute potential supportive therapeutics for OM.

Onicomicoses por fungos do gênero Candida: uma revisão de literatura

The information present in this research serves as an aid for the consolidation of clinical - epidemiological knowledge that focuses on onychomycosis, caused by fungi of the genus Candida, including students, health professionals, academics and all society.

The Growing Problem of Antifungal Resistance in Onychomycosis and Other Superficial Mycoses

The majority of reports of recalcitrant infections indicate terbinafine resistance as the causative factor, and single-point mutations in the squalene oxidase gene is the most reported mechanism of resistance to terBinafine.



Onychomycosis: Pathogenesis, Diagnosis, and Management

  • B. Elewski
  • Medicine
    Clinical Microbiology Reviews
  • 1998
Onychomycosis is more difficult to treat than most dermatophytoses because of the inherent slow growth of the nail, and three recently developed antimycotic agents offer high cure rates and good safety profiles.

Onychomycosis in the Elderly

It is important to counsel patients on the strategies of reducing recurrence of disease, and to confirm the clinical impression of onychomycosis should be confirmed by mycological examination, whenever possible.

Tavaborole for the treatment of onychomycosis

Tavaborole topical solution, 5% may become a safe and effective option for the treatment of onychomycosis when approved and is demonstrated by a clinical development program including in vitro data and two large Phase III trials that enrolled 1200 patients.

Oral Therapy for Onychomycosis: An Evidence-Based Review

In the majority of the studies, terbinafine treatment showed a higher cure ratio than the other drugs for dermatophyte onychomycosis, and the azoles, mainly itraconazole, are the recommended therapy.

Spotlight on tavaborole for the treatment of onychomycosis

The landscape of topical and systemic treatment of onychomycosis is reviewed, with particular attention to the pharmacokinetics, safety, and efficacy of topical tavaborole.

The role of nondermatophyte molds in onychomycosis: diagnosis and treatment

Better, faster, and cheaper methods of identifying etiologic agents, investigations as to how to demonstrate nail invasion, and studies to determine treatment efficacy, outcome, and necessity are needed.

Pharmacokinetics of Antifungal Agents in Onychomycoses

Onychomycosis is caused by infection by fungi, mainly dermatophytes and nondermatophyte yeasts or moulds; it affects the fingernails and, more frequently, the toenails. Dermatophytes are responsible

How effective is efinaconazole in the management of onychomycosis?

Efinaconazole is a safe and effective treatment for onychomycosis that can be used in a wide range of patients due to its broad-spectrum antifungal activity and low rate of treatment-related adverse events.

New therapeutic options for onychomycosis

The emerging pharmacotherapeutics; including topical reformulations of terbinafine, new azole molecules for systemic and topical administration, topical benzoxaboroles and topical polymer barriers, are discussed, which may be designed to activate a drug or to improve drug delivery.