Ontogeny of the serotonergic system in the rat: serotonin as a developmental signal.

  • Jean M. Lauder
  • Published 1990 in Annals of the New York Academy of Sciences


The serotonergic system is an early forming component of the CNS circuitry, beginning its development on gestational days 11-12 in the rat. Owing to its early presence in the embryonic nervous system, 5-HT has been proposed to act as a developmental signal for receptive cells. In vivo and in vitro evidence that 5-HT can influence both biochemical and… (More)