Ontogeny of the extracellular calcium-sensing receptor in rat kidney.

  title={Ontogeny of the extracellular calcium-sensing receptor in rat kidney.},
  author={Naibedya Chattopadhyay and Michelle Amy Baum and M. Geetha Bai and Daniela M. dos R. Riccardi and Steven C. Hebert and Hobart W. Harris and Edward Meigs Brown},
  journal={The American journal of physiology},
  volume={271 3 Pt 2},
We recently cloned extracellular Ca(2+)-sensing receptors (CaRs) from bovine parathyroid and rat kidney that play key roles in Ca2+ homeostasis. Inactivating mutations of the CaR in the inherited human disorder, familial hypocalciuric hypercalcemia, cause reduced responsiveness of the parathyroid to extracellular Ca2+ (Cao2+), as well as abnormally avid renal tubular reabsorption of both Ca2+ and Mg2+ in the distal tubule, suggesting an important role for the CaR in regulating parathyroid… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 24 extracted citations

The calcium-sensing receptor and related diseases.

Arquivos brasileiros de endocrinologia e metabologia • 2006
View 6 Excerpts
Highly Influenced

Calcium-sensing receptor 20 years later.

American journal of physiology. Cell physiology • 2014
View 11 Excerpts
Highly Influenced

Protein-induced satiation and the calcium-sensing receptor

Diabetes, metabolic syndrome and obesity : targets and therapy • 2018

Similar Papers

Loading similar papers…