Ontogeny of the extracellular calcium-sensing receptor in rat kidney.

@article{Chattopadhyay1996OntogenyOT,
  title={Ontogeny of the extracellular calcium-sensing receptor in rat kidney.},
  author={Naibedya Chattopadhyay and Michelle Amy Baum and M. Geetha Bai and Daniela M. dos R. Riccardi and Steven C. Hebert and Hobart W. Harris and Edward Meigs Brown},
  journal={The American journal of physiology},
  year={1996},
  volume={271 3 Pt 2},
  pages={F736-43}
}
We recently cloned extracellular Ca(2+)-sensing receptors (CaRs) from bovine parathyroid and rat kidney that play key roles in Ca2+ homeostasis. Inactivating mutations of the CaR in the inherited human disorder, familial hypocalciuric hypercalcemia, cause reduced responsiveness of the parathyroid to extracellular Ca2+ (Cao2+), as well as abnormally avid renal tubular reabsorption of both Ca2+ and Mg2+ in the distal tubule, suggesting an important role for the CaR in regulating parathyroid… CONTINUE READING

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