Ontogeny of the enhanced behavioral response to amphetamine in amphetamine-pretreated rats

@article{Kolta1990OntogenyOT,
  title={Ontogeny of the enhanced behavioral response to amphetamine in amphetamine-pretreated rats},
  author={Malak G Kolta and Frank M. Scalzo and S. Fatehyab Ali and R. Robert Holson},
  journal={Psychopharmacology},
  year={1990},
  volume={100},
  pages={377-382}
}
Repeated administration of amphetamine to adult rats results in enhanced behavioral responses to subsequent amphetamine exposure. These experiments were designed to determine the earliest age at which behavioral sensitization to amphetamine could be detected. Rats from both sexes (n=6–8/group) at ages of 1, 7, 21 or 49 postnatal days (PNDs) were injected with eitherd-amphetamine sulfate (5 mg/kg) or saline, SC, twice daily for 5 consecutive days. Stereotyped behavior and locomotor activity… CONTINUE READING

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Time - course of the development of the enhanced behavioral and biochemical responses to amphetamine after pretreatment with amphetamine

  • MG Kolta, P Shreve, V DeSouza, NJ Uretsky
  • Neuropharmacology
  • 1985

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