Ontogeny of rabbit proximal tubule urea permeability.

  title={Ontogeny of rabbit proximal tubule urea permeability.},
  author={Raymond Quigley and Anka Lisec and Michel Baum},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  volume={280 6},
Urea transport in the proximal tubule is passive and is dependent on the epithelial permeability. The present study examined the maturation of urea permeability (P(urea)) in in vitro perfused proximal convoluted tubules (PCT) and basolateral membrane vesicles (BLMV) from rabbit renal cortex. Urea transport was lower in neonatal than adult PCT at both 37 and 25 degrees C. The PCT P(urea) was also lower in the neonates than the adults (37 degrees C: 45.4 +/- 10.8 vs. 88.5 +/- 15.2 x 10(-6) cm/s… CONTINUE READING


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