Ontogeny of proteolytic immunity: IgM serine proteases.

  title={Ontogeny of proteolytic immunity: IgM serine proteases.},
  author={Stephanie A. Planque and Yogesh A. Bangale and X Song and Sangeeta Karle and Hiroaki Taguchi and Brian J. Poindexter and Roger J. Bick and Allen B. Edmundson and Yasuhiro Nishiyama and Sudhir Paul},
  journal={The Journal of biological chemistry},
  volume={279 14},
We report the chemical activity of immunoglobulin micro and kappa/lambda subunits expressed on the surface of B cells and in secreted IgM antibodies (Abs) found in the preimmune repertoire. Most of the nucleophilic reactivity of B cells measured by formation of covalent adducts of a hapten amidino phosphonate diester was attributed to micro and kappa/lambda subunits of the B cell receptor. Secreted IgM Abs displayed superior nucleophilic reactivity than IgG Abs. IgM Abs catalyzed the cleavage… CONTINUE READING


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