Ontogeny of mu opioid agonist anti-nociception in postnatal rats.

  title={Ontogeny of mu opioid agonist anti-nociception in postnatal rats.},
  author={Simon R Thornton and David R. Compton and Forrest L. Smith},
  journal={Brain research. Developmental brain research},
  volume={105 2},
Mu opiate agonists morphine, fentanyl and meperidine are administered short-term to pediatric patients, from the neonatal period through adolescence. However, there has been no assessment of the effect of age on the analgesic efficacy or the concentration-response relationship for these opioids in human pediatric patients. Few studies in animals have correlated opioid anti-nociception and tissue levels of these opioids commonly administered to pediatric patients. The present study was conducted… CONTINUE READING