Ontogeny of growth-regulating genes in the placenta.

  title={Ontogeny of growth-regulating genes in the placenta.},
  author={Neeru Kumar and Jeremy T Leverence and Debra Bick and Venkatesh Sampath},
  volume={33 2},
BACKGROUND Placental nutrient flow is the primary determinant of fetal growth. This key function of the placenta depends on several growth-promoting or -suppressing imprinted genes including Insulin-like growth factor [IGF] axis genes, which regulate nutrient transfer across the placenta. However whether changes in the placental expression of these genes parallel increased fetal growth observed in the second and third trimester remains unknown. OBJECTIVE The aim of our study was to determine… CONTINUE READING

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