Ontogeny of gamma-glutamyltransferase in the rat lung.

  title={Ontogeny of gamma-glutamyltransferase in the rat lung.},
  author={stephen. oakes and Yuji Takahashi and Mary C. Williams and Martin F Joyce-Brady},
  journal={The American journal of physiology},
  volume={272 4 Pt 1},
gamma-Glutamyltransferase (gamma-GT) is a key enzyme in the metabolism of glutathione and glutathione-substituted molecules. The gamma-GT gene is expressed in two epithelial cells of the adult lung, the bronchiolar Clara cell and the alveolar type II cell. Because pulmonary glutathione metabolism may be important in the perinatal period, we studied gamma-GT ontogeny in the developing rat lung. In the late fetal and early postnatal lung, gamma-GT mRNA was below detectable limits on Northern… CONTINUE READING