Ontogeny of Recognition Specificity and Functionality for the Broadly Neutralizing Anti-HIV Antibody 4E10

@inproceedings{Finton2014OntogenyOR,
  title={Ontogeny of Recognition Specificity and Functionality for the Broadly Neutralizing Anti-HIV Antibody 4E10},
  author={Kathryn A. K. Finton and Della Friend and James Bertram Jaffe and Mesfin Mulugeta Gewe and Margaret A. Holmes and Harry Benjamin Larman and Andrew Stuart and Kevin Scott Larimore and Philip D. Greenberg and Stephen J Elledge and Leonidas Stamatatos and Roland K. Strong and Georgia D. Tomaras},
  booktitle={PLoS pathogens},
  year={2014}
}
The process of antibody ontogeny typically improves affinity, on-rate, and thermostability, narrows polyspecificity, and rigidifies the combining site to the conformer optimal for binding from the broader ensemble accessible to the precursor. However, many broadly-neutralizing anti-HIV antibodies incorporate unusual structural elements and recognition specificities or properties that often lead to autoreactivity. The ontogeny of 4E10, an autoreactive antibody with unexpected combining site… CONTINUE READING

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  • The Journal of allergy and clinical immunology
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