Ontogeny of Insulin-Like Growth Factor-Binding Protein-1, −2, and −3: Quantitative Measurements by Radioimmunoassay in Human Fetal Serum

@article{Bang1994OntogenyOI,
  title={Ontogeny of Insulin-Like Growth Factor-Binding Protein-1, −2, and −3: Quantitative Measurements by Radioimmunoassay in Human Fetal Serum},
  author={Peter Bang and Magnus MW Westgren and Juerg Schwander and Werner Friedrich Blum and Ron G. Rosenfeld and Magnus Stangenberg},
  journal={Pediatric Research},
  year={1994},
  volume={36},
  pages={528-535}
}
ABSTRACT: There is evidence for a role for IGF-I in the endocrine control of human fetal growth despite the low serum IGF-I concentrations. The formation in serum of binary complexes between IGF-I or -II and either of six IGF binding proteins (IGFBP-1 to −6) and, in particular, of long-lived ternary complexes between IGF-I or -II, IGFBP-3, and acid-labile subunit is thought to regulate IGF-I bioavailabil-ity by increasing its serum half-life. The present study assesses the bioavailability of… CONTINUE READING