Ontogeny of Hepatic Drug Transporters as Quantified by LC-MS/MS Proteomics.

Abstract

Protein expression of major hepatic uptake and efflux drug transporters in human pediatric (n = 69) and adult (n = 41) livers was quantified by liquid chromatography / tandem mass spectroscopy (LC-MS/MS). Transporter protein expression of OCT1, OATP1B3, P-gp, and MRP3 was age-dependent. Particularly, significant differences were observed in transporter… (More)
DOI: 10.1002/cpt.409

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