Ontogeny of Ca 2-induced Ca 2 release in rabbit ventricular myocytes

  title={Ontogeny of Ca 2-induced Ca 2 release in rabbit ventricular myocytes},
  author={Jingbo Huang and L. Hove-Madsen and Glen F. Tibbits},
Huang J, Hove-Madsen L, Tibbits GF. Ontogeny of Ca -induced Ca release in rabbit ventricular myocytes. Am J Physiol Cell Physiol 294: C516–C525, 2008. First published December 19, 2007; doi:10.1152/ajpcell.00417.2007.—It is commonly accepted that L-type Ca channel-mediated Ca -induced Ca release (CICR) is the dominant mode of excitation-contraction (E-C) coupling in the adult mammalian heart and that there is no appreciable CICR in neonates. However, we have observed that cell contraction in… CONTINUE READING


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