Ontogeny of Amino Acid Metabolism in Mammalian Kidney

  title={Ontogeny of Amino Acid Metabolism in Mammalian Kidney},
  author={K. Baerlocher and C. Scriver and F. Mohyuddin},
  journal={Pediatric Research},
  • K. Baerlocher, C. Scriver, F. Mohyuddin
  • Published 1970
  • Biology
  • Pediatric Research
  • Mammalian kidney transports imino-acids and glycine at physiological concentrations on three t ypes of membrane sites: a low-Km proline system, a low-Km glycine system and a ‘common’ high-Km system. Our recent studies (in press) show that absence of the two low-Km systems accounts for postnatal iminoglycinuria in mammals. Further studies with newborn rat kidney reveal additional ontogenetic features. Uptake: The low-Km proline system becomes active 1 week after birth. The low-Km glycine system… CONTINUE READING
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