Ontogeny and topography of seizure regulation by the substantia nigra.

@article{Mosh1995OntogenyAT,
  title={Ontogeny and topography of seizure regulation by the substantia nigra.},
  author={Solomon L Mosh{\'e} and Doroth{\'e}e Garant and Ellen F Sperber and Jana Vel{\'i}{\vs}kov{\'a} and Hana Kubov{\'a} and Lucy L. Brown},
  journal={Brain & development},
  year={1995},
  volume={17 Suppl},
  pages={61-72}
}
The substantia nigra pars reticulata (SNR) is a structure involved in the control of seizures, and its effects on seizures are age-dependent. GABAergic transmission in the SNR, mediated by GABAA receptors, influences seizure susceptibility. We have found that in the adult SNR there may be at least two segregated GABAA-sensitive SNR projection networks involved in regulating the SNR effects on seizures, perhaps reflecting the existence of an anticonvulsant and a proconvulsant network. The two… CONTINUE READING