Ontogeny and the effect of aging on pancreatic polypeptide and peptide YY

@article{Sandstrm2002OntogenyAT,
  title={Ontogeny and the effect of aging on pancreatic polypeptide and peptide YY},
  author={Olof Sandstr{\"o}m and Magdy El-Salhy},
  journal={Peptides},
  year={2002},
  volume={23},
  pages={263-267}
}
PYY in the expanding pancreatic epithelium
TLDR
The data suggest that PYY may be a mediator of islet cell development, as well as a cofactor for growth factor responses, not only during fetal pancreas formation but also during regeneration in adult animals.
Molecular cloning, tissue and embryonic development expression, and appetite regulatory effect of pancreatic peptide Y in Coilia nasus
TLDR
A potential role for PY in appetite regulation is revealed and provides a basis for further study of Py in C. nasus, suggesting a potential relationship between food intake and the expression of PY.
Reg IV is differently expressed in enteroendocrine cells of human small intestine and colon
The role of peptide YY in gastrointestinal diseases and disorders
TLDR
Investigating changes in PYY in gastrointestinal diseases/disorders could be beneficial in clinical practice, where a receptor agonist or an antagonist can be used as a drug, depending on the condition.
The Gastrointestinal System and Aging
TLDR
The chapter discusses morphological and physiological changes with age in the GI system and provides clinical applications where relevant.
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References

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PYY in developing murine islet cells: comparisons to development of islet hormones, NPY, and BrdU incorporation.
TLDR
Results suggest that PYY-positive endocrine cells may represent precursors for mature islet cells, consistent with a precursor role of triple-positive (insulin+glucagon+PYY) cells.
The distribution and ontogeny of polypeptide YY (PYY)-and pancreatic polypeptide (PP)-immunoreactive cells in the gastrointestinal tract of rat
TLDR
The difference between PYY-and PP-immunoreactive cells in the distribution, frequency and ontogeny provide further evidence that PYY and PP occur in two independent cell types.
Development of hormonal peptides and processing enzymes in the embryonic avian pancreas with special reference to co-localisation
TLDR
The paucity of cells co-expressing insulin and glucagon indicate that all avian insulin cells do not pass through a stage where they co- express glucagon, and the early expression of the enzymes responsible for the processing of prohormones suggests that this process is initiated soon after islet cells first differentiate.
Peptide YY expression is an early event in colonic endocrine cell differentiation: evidence from normal and transgenic mice.
The hormone peptide YY is produced by endocrine cells in the pancreas, ileum and colon. We have previously shown that peptide YY is coexpressed in all four islet cell types in the murine pancreas
Expression of peptide YY in all four islet cell types in the developing mouse pancreas suggests a common peptide YY-producing progenitor.
TLDR
The use of conditions that distinguish peptide YY from the related peptides, pancreatic polypeptide and neuropeptid Y, as well as the ability of the peptideYY gene to direct expression of a reporter gene in islets of transgenic mice, establishes expression of peptide yY in the earliest pancreatic endocrine cells.
ONTOGENY OF POLYPEPTIDE YY (PYY) CELLS IN THE GUT OF CHICKEN: AN IMMUNOCYTOCHEMICAL STUDY
The occurrence of polypeptide YY (PYY) immunoreactive cells was investigated in various parts of the alimentary tract of chick embryos from 60 h to 18 days of incubation and of chicken from l to 4
Developmental patterns of glucagon-like peptide-1-(7-36) amide and peptide-YY in rat pancreas and gut.
TLDR
A complex and specific regulation of posttranslational processing during maturation for these two peptides is revealed and it is revealed that only GLP-1-(7-36) amide is produced during intestinal development.
Intestinal peptide YY: ontogeny of gene expression in rat bowel and trophic actions on rat and mouse bowel.
TLDR
The trophic effects of PYY were dose related, peptide specific, and independent of species and sex, hypothesize that PYY plays an important role in intestinal development and dietary adaptation in rats and mice.
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