Ontogeny and functions of central nervous system macrophages.

@article{Katsumoto2014OntogenyAF,
  title={Ontogeny and functions of central nervous system macrophages.},
  author={Atsuko Katsumoto and Haiyan Lu and Aline Silva de Miranda and Richard M Ransohoff},
  journal={Journal of immunology},
  year={2014},
  volume={193 6},
  pages={2615-21}
}
Microglia, the only nonneuroepithelial cells found in the parenchyma of the CNS, originate during embryogenesis from the yolk sac and enter the CNS quite early (embryonic day 9.5-10 in mice). Thereafter, microglia are maintained independently of any input from the blood and, in particular, do not require hematopoietic stem cells as a source of replacement for senescent cells. Monocytes are hematopoietic cells, derived from bone marrow. The ontogeny of microglia and monocytes is important for… CONTINUE READING
35 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 35 extracted citations

Similar Papers

Loading similar papers…