Ontogeny and functions of central nervous system macrophages.

  title={Ontogeny and functions of central nervous system macrophages.},
  author={Atsuko Katsumoto and Haiyan Lu and Aline Silva de Miranda and Richard M Ransohoff},
  journal={Journal of immunology},
  volume={193 6},
Microglia, the only nonneuroepithelial cells found in the parenchyma of the CNS, originate during embryogenesis from the yolk sac and enter the CNS quite early (embryonic day 9.5-10 in mice). Thereafter, microglia are maintained independently of any input from the blood and, in particular, do not require hematopoietic stem cells as a source of replacement for senescent cells. Monocytes are hematopoietic cells, derived from bone marrow. The ontogeny of microglia and monocytes is important for… CONTINUE READING
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