Ontogeny and effect of activity on proenkephalin mRNA expression during development of the chick spinal cord.

@article{Garner1994OntogenyAE,
  title={Ontogeny and effect of activity on proenkephalin mRNA expression during development of the chick spinal cord.},
  author={L K Garner and Bilha Mendelson and Kathryn M Albers and Mark Kindy and T L Overbeck and Brigid M. Davis},
  journal={The Journal of comparative neurology},
  year={1994},
  volume={347 1},
  pages={36-46}
}
Numerous studies have shown in the adult nervous system that mRNA expression can be regulated by neuronal activity. To examine the effect of activity during embryogenesis, the ontogeny of proenkephalin mRNA expression and expression following activity blockade was investigated during development of chick spinal cord. A cDNA fragment (ca. 0.5 kb) coding for chick proenkephalin was cloned and sequenced. With this cDNA, a cRNA probe was made to examine proenkephalin mRNA expression in the spinal… CONTINUE READING

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