Ontogeny, function, and peripheral homeostasis of regulatory T cells in the absence of interleukin-7.

@article{Latour2006OntogenyFA,
  title={Ontogeny, function, and peripheral homeostasis of regulatory T cells in the absence of interleukin-7.},
  author={R{\'e}gis Peffault de Latour and H{\'e}l{\`e}ne C. Dujardin and Florence Mishellany and Odile Burlen-defranoux and Julien Zuber and R. Intini Marques and James P Di Santo and Ana Cumano and Paulo Vieira and Ant{\^o}nio Bandeira},
  journal={Blood},
  year={2006},
  volume={108 7},
  pages={2300-6}
}
Mice lacking interleukin-7 (IL-7-/- mice) have no signs of autoimmune disease, contrary to other models of lymphopenia. We investigated whether the absence of disease was due to the fact that IL-7 is dispensable for the ontogeny, function, and homeostasis of regulatory CD4+ T cells. We show here that the establishment of the peripheral pool of Foxp3-expressing regulatory cells is IL-7 independent, and the premature involution of the thymus in IL-7-/- mice does not change the representation of… CONTINUE READING
18 Citations
41 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 18 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 41 references

CD25- T cells generate CD25 Foxp3 regulatory T cells by peripheral expansion

  • MA Curotto de Lafaille, AC Lino, N Kutchukhidze, JJ. Lafaille
  • J Immunol
  • 2004

Similar Papers

Loading similar papers…