Ontogeny, conservation and functional significance of maternally inherited DNA methylation at two classes of non-imprinted genes

@inproceedings{Rutledge2014OntogenyCA,
  title={Ontogeny, conservation and functional significance of maternally inherited DNA methylation at two classes of non-imprinted genes},
  author={Charlotte E. Rutledge and Avinash Thakur and Karla M. O’Neill and Rachelle Elizabeth Irwin and Shun Sato and Ken Ichiro Hata and Colum P Walsh},
  booktitle={Development},
  year={2014}
}
A functional role for DNA methylation has been well-established at imprinted loci, which inherit methylation uniparentally, most commonly from the mother via the oocyte. Many CpG islands not associated with imprinting also inherit methylation from the oocyte, although the functional significance of this, and the common features of the genes affected, are unclear. We identify two major subclasses of genes associated with these gametic differentially methylated regions (gDMRs), namely those… CONTINUE READING

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