Ontogenetic profile of the adenosine uptake sites in rat forebrain.


The ontogenesis of rat forebrain adenosine uptake sites labelled by [3H]nitrobenzylthioinosine ([3H]NBI) was determined and compared to that of rat forebrain adenosine receptors labelled by N6-cyclohexyl[3H]adenosine ([3H]-CHA). [3H]NBI binding is highly invariant with similar levels of [3H]NBI binding sites from embryonic day 19 to day 30 postpartum. Scatchard and Hill analyses reveal the binding of [3H]NBI in 6-day-old tissue to be indistinguishable from such binding in 30-day-old tissue. In contrast, [3H]-CHA binding is highly variant. [3H]CHA binding develops slowly but steadily from about embryonic day 19, with adult binding levels being achieved at around 25 days postpartum. The ontogenetic profile of [3H]CHA appears to coincide with synaptogenesis whereas that of [3H]NBI does not.


Citations per Year

376 Citations

Semantic Scholar estimates that this publication has 376 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Morgan1987OntogeneticPO, title={Ontogenetic profile of the adenosine uptake sites in rat forebrain.}, author={Philip F. Morgan and Paula Montgomery and Paul J. Marangos}, journal={Journal of neurochemistry}, year={1987}, volume={49 3}, pages={852-5} }