Ontogenetic Patterning of Human Subchondral Bone Microarchitecture in the Proximal Tibia

@article{Goliath2022OntogeneticPO,
  title={Ontogenetic Patterning of Human Subchondral Bone Microarchitecture in the Proximal Tibia},
  author={Jesse R. Goliath and James H. Gosman and Sam D. Stout and Timothy M Ryan},
  journal={Biology},
  year={2022},
  volume={11}
}
Simple Summary The objective of this study is to explain the subchondral trabecular and the cortical ontogenetic changes that occur in the proximal tibia in both the medial and lateral condylar regions due to differential loadings associated with changing knee joint kinetics and body mass. The differential response of subchondral bone to changing mechanical loads during growth and development serves as a powerful tool to evaluate the significance of mechanical loading on subchondral bone… 
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References

SHOWING 1-10 OF 349 REFERENCES

Development of Cortical Bone Geometry in the Human Femoral and Tibial Diaphysis

The data reveal that the femoral and tibial midshaft shape are relatively conserved throughout growth; yet, conversely, the proximal and distal femoral diaphysis and proximal tibials appear more sensitive to developmentally induced changes in mechanical loading.

Microarchitectural adaptations in aging and osteoarthrotic subchondral bone issues

  • M. Ding
  • Biology, Medicine
    Acta orthopaedica. Supplementum
  • 2010
The overall goals of the current series of studies were to investigate the age-related and osteoarthrosis related changes in the 3-D microarchitectural properties, mechanical properties, collagen and mineral quality of subchondral cancellous and cortical bone tissues.

Age-Related Three-Dimensional Microarchitectural Adaptations of Subchondral Bone Tissues in Guinea Pig Primary Osteoarthrosis

Significant alterations of the microarchitecture and bone matrix composition of the subchondral bone did not appear to follow the same pattern as in normal aging and may have different influences on the resulting mechanical properties.

Trabecular bone ontogeny in the human proximal femur.

Ontogenetic changes to bone microstructure in an archaeologically derived sample of human ribs

Cortical porosity data are not correlated with two‐dimensional measures of osteon population density (OPD), which suggests that unfilled resorption spaces contribute more significantly to cortical porosity than do the Haversian canals of secondary osteons.

Topographical variations in articular cartilage and subchondral bone of the normal rat knee are age-related.

Ontogenetic Patterning of Cortical Bone Microstructure and Geometry at the Human Mid‐Shaft Femur

On the basis of the presence of transitional fibrolamellar bone complex, growth is more rapid during the toddler years and peri‐puberty, and slower in early to late childhood and in later adolescence.

Studies of tibial subchondral bone density and its significance.

There is a trinitarian relationship between the meniscus, cartilage, and subchondral bone, in which structural changes in any one of the three causes secondary pathological adaptive changes in the other two.

Subchondral Bone Plate Changes More Rapidly than Trabecular Bone in Osteoarthritis

The rapid early changes in SbpTh, TbTh, Sbp BMD and Tb BMD in the disease prone DH guinea pigs compared with the BS2 control strain suggest a link to early OA pathology.
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