Ontogenetic Diurnal Variation of Adrenal Responsiveness to ACTH and Stress in Rats

@article{Leal1999OntogeneticDV,
  title={Ontogenetic Diurnal Variation of Adrenal Responsiveness to ACTH and Stress in Rats},
  author={Angela M. O. Leal and Jordana Carvalho and Ayrton Custodio Moreira},
  journal={Hormone Research in Paediatrics},
  year={1999},
  volume={52},
  pages={25 - 29}
}
We performed studies in 8-, 16-, 24-, 30 and 35-day-old Wistar rats at 8.00 h (AM) and 20.00 h (PM) to investigate the relationship between the diurnal variations of basal plasma corticosterone (compound B, CB) and its responses to ACTH and ether stress during the postnatal period. Basal plasma CB levels increased at PM from 8 to 35 days of age and an AM-PM difference was observed at 16 days. Although an AM-PM difference in CB responsiveness to ACTH was detected only at 24 and 35 days, ACTH… 

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