Ontogenetic Alterations in Molecular and Structural Correlates of Dendritic Growth after Developmental Exposure to Polychlorinated Biphenyls

@inproceedings{Lein2007OntogeneticAI,
  title={Ontogenetic Alterations in Molecular and Structural Correlates of Dendritic Growth after Developmental Exposure to Polychlorinated Biphenyls},
  author={Pamela J Lein and Dongren Yang and Adam D. Bachstetter and Hugh A. Tilson and G Jean Harry and Ronald F. Mervis and Prasada Rao S. Kodavanti},
  booktitle={Environmental health perspectives},
  year={2007}
}
OBJECTIVE Perinatal exposure to polychlorinated biphenyls (PCBs) is associated with decreased IQ scores, impaired learning and memory, psychomotor difficulties, and attentional deficits in children. It is postulated that these neuropsychological deficits reflect altered patterns of neuronal connectivity. To test this hypothesis, we examined the effects of developmental PCB exposure on dendritic growth. METHODS Rat dams were gavaged from gestational day 6 through postnatal day (PND) 21 with… CONTINUE READING