Ontogenesis of kappa-opioid receptors in rat brain using [3H]U-69593 as a binding ligand.

@article{Kitchen1990OntogenesisOK,
  title={Ontogenesis of kappa-opioid receptors in rat brain using [3H]U-69593 as a binding ligand.},
  author={I. Kitchen and Maureen Kelly and Mar{\'i}a Paz Viveros},
  journal={European journal of pharmacology},
  year={1990},
  volume={175 1},
  pages={93-6}
}
The ontogenesis of kappa-opioid receptors has been studied in the postnatal period from day 5 to day 30 using the highly selective kappa-site ligand [3H]U-69593 in binding studies. Analyses of saturation curves revealed a marked increase in the binding capacities between day 5 and day 10 with no further increment in the number of sites up to adult ages confirming a distinct ontogenetic profile from mu- and delta-sites. When expressed per mg protein the number of sites declined from day 10 to… CONTINUE READING