Onset of obesity in carboxypeptidase E-deficient mice and effect on airway responsiveness and pulmonary responses to ozone.

@article{Johnston2010OnsetOO,
  title={Onset of obesity in carboxypeptidase E-deficient mice and effect on airway responsiveness and pulmonary responses to ozone.},
  author={Richard A Johnston and Ming Zhu and C. Bustillo Hern{\'a}ndez and Erin D. Williams and Stephanie A. Shore},
  journal={Journal of applied physiology},
  year={2010},
  volume={108 6},
  pages={1812-9}
}
When compared with lean, wild-type mice, obese Cpefat mice, 14 wk of age and older, manifest innate airway hyperresponsiveness (AHR) to intravenous methacholine and enhanced pulmonary inflammation following acute exposure to ozone (O3). The purpose of this study was to examine the onset of these augmented pulmonary responses during the onset of obesity. Thus airway responsiveness and O3-induced pulmonary inflammation and injury were examined in 7- and 10-wk-old Cpefat and age-matched, wild-type… CONTINUE READING