Onset of mechanical activation of mammalian heart muscle in calcium- and strontium-containing solutions.

@article{Brutsaert1974OnsetOM,
  title={Onset of mechanical activation of mammalian heart muscle in calcium- and strontium-containing solutions.},
  author={Dirk L. Brutsaert and Victor Claes},
  journal={Circulation research},
  year={1974},
  volume={35 3},
  pages={345-57}
}
The time course of the relationship between force, shortening velocity, and length during shortening was examined in mammalian heart muscle in calcium (Ca)-containing solutions and solutions with strontium (Sr) substituted for Ca by imposing load clamps of various amplitudes at various times during external shortening. The onset of this force-velocity-length relationship was measured by abruptly unloading the muscle at different times to nearly zero external load—by zero load clamping the… CONTINUE READING

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