Onset of cell-specific gene expression in the developing mouse pancreas.

  title={Onset of cell-specific gene expression in the developing mouse pancreas.},
  author={George K. Gittes and William J. Rutter},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={89 3},
A central question in developmental biology has been the initiation of cell-specific gene expression and its temporal relationship to morphogenesis. We have coupled embryo microdissection with the exquisite sensitivity of the polymerase chain reaction to define the onset of cell-specific gene expression during pancreatic organogenesis. Using the precise assignment of gestational age by the number of somites in each embryo, we determined the onset of transcription of major genes of the endocrine… CONTINUE READING


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