Onset of cardiac iron loading in pediatric patients with thalassemia major.

@article{Wood2008OnsetOC,
  title={Onset of cardiac iron loading in pediatric patients with thalassemia major.},
  author={John C. Wood and Raffaella Origa and Annalisa Agus and G Matta and Thomas D. Coates and Renzo Galanello},
  journal={Haematologica},
  year={2008},
  volume={93 6},
  pages={917-20}
}
We reviewed cardiac T2* assessments from 77 thalassemia major patients between the ages of 2.5 and 18 years to study optimal timing of cardiac iron screening by magnetic resonance imaging. No patient under 9.5 years of age showed detectable cardiac iron in contrast to 36% of patients between the ages of 15-18 years old, corresponding to an odds-ratio of 1.28 (28%) per year. All patients with cardiac iron had received at least 35 grams of transfusional iron. Liver iron and ferritin failed to… CONTINUE READING
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