Onset of audiogenic seizures in rodents after intake of near-toxic doses of rubidium chloride.

@article{Alexander1975OnsetOA,
  title={Onset of audiogenic seizures in rodents after intake of near-toxic doses of rubidium chloride.},
  author={George J. Alexander and Herbert L. Meltzer},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1975},
  volume={194 3},
  pages={480-7}
}
Rats and mice that were not genetically or otherwise predisposed toward audiogenic seizures were rendered susceptible to auditory stimuli by chronic treatment with large doses of rubidium chloride (RbCl). Animals given drinking water, 0.03 N with respect to RbCl, for four weeks responded with convulsive seizures when exposed to signals of 2 to 22 kHz and 74 dbA. The rate of development of audiosusceptibility was dose-related. Less rubidium was needed if the diet was deficient in potassium. No… CONTINUE READING

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